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February 19th, 2020 |
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9:00-10:45 |
Registration + Coffee |
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10:45-11:00 |
GEQB – Opening Mario Delgado, IPBLN-CSIC, Granada, Spain Juan Carlos Morales, IPBLN-CSIC, Granada, Spain |
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11:00-13:30 |
Session 1 Chair: Juan Carlos Morales
11:00-11:45 Plenary Lecture (sponsored by “Molecules”, MDPI) A chemistry-based multidisciplinary strategy to semi-synthetic glycovaccines: from concept to first-in-human study and more in the context of Shigella Laurence A. Mulard, Institute Pasteur, France
11:45-12:15 Invited Lecture Impact of Biophysical Techniques on Drug Discovery Juan Félix Espinosa, Lilly, Madrid, Spain
12:15-12:45 Invited Lecture Turning stem cells into a medicine Mario Delgado, IPBLN-CSIC, Granada, Spain
12:45-13:15 Oral Communications OC1. Glycodendropeptides as potential synthetic vaccines against allergy Javier Rojo, IIQ-CSIC, Seville, Spain OC2. Development of new streamlined saponin vaccine adjuvants: molecular-level insights into saponin conformation correlating with adjuvant activity Alberto Fernández-Tejada, Cicbiogune, Bilbao, Spain
13:15-13:30 Flash Communications FC1. Pablo Valverde, NMR Studies of the specific interaction of DC-SIGN with the blood group A/B antigens FC2. Beatriz Fernández de Toro, Avenues to characterize the interactions of extended N-glycans with proteins by NMR spectroscopy: the influenza hemagglutinin case FC3. Manuel González Cuesta, Enzyme regulators with self-delivery capabilities |
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13:30-15:00 |
Lunch |
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15:00-16:30 |
Session 2 Chair: Rosario Sánchez Martín
15:00-15:30 Invited Lecture Multi-Scale Approaches to Computer-Assisted Enzyme Design Gonzalo Jiménez-Oses, CICBiogune, Bilbao, Spain
15:30-16:00 Invited Lecture Efficient and Sustainable Synthesis of Muramic and Glucuronic acid Glycodendrimers as Dengue Virus Antagonists María José Hernáiz Gómez, Universidad Complutense, Madrid, Spain
16:00-16:15 Oral Communication OC3. sp2-Iminosugar glycolipid mimetics as immunoregulatory agents Elena M. Sánchez, University of Seville, Spain
16:15-16:30 Flash Communications FC4. Alejandra Matamoros Recio, Computational approaches to the structure and activation mechanism of Toll-like receptor 4 FC5. José Antonio Laz-Ruiz, TDesign and development of novel nanodevices for biomedical applications FC6. María Pia Lenza, Deciphering the N-glycan profile and interactions of FcɛRIα by NMR
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16:30-17:00 |
Coffee break + Poster session 1 |
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17:00-18:30 |
Session 3 Chair: Ignacio Alfonso
17:00-17:30 Invited Lecture Designing the 3D microenvironment of cells for the bioengineering of humanized tissues Joao Mano, University of Aveiro, Portugal
17:30-18:00 Invited Lecture Discovery of Novel Spirocycles as Inhibitors of the Mitochondrial Permeability Transition Pore Opening for the Treatment of Myocardial Reperfusion Injury Delia Preti, University of Ferrara, Italy
18:00-18:15 Oral Communication OC4. Interaction of amyloid-β with functionalised gold nanoparticles Patrick Gámez, University of Barcelona, Spain
18:15-18:30 Flash Communications FC7. Reyes Núnez Franco, Computational prediction of activity-enhancing mutations by allosteric networks optimization FC8. María Dolores Moya Garzón, Development of salicylate derivatives with double GO/LDHA inhibitory activity as pharmacological approach for the treatment of primary hyperoxaluria type 1 FC9. Marta Pazo Pascual, Lipid responsive helical oligoalanines for cell penetration
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18:30-19:00 |
Meeting - GEQB |
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February 20th, 2020 |
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9:00-11:00 |
Session 4 Chair: José Luis Mascareñas
9:00-9:45 Plenary Lecture (sponsored by “Pharmaceuticals”, MDPI) The Chemistry-medicine continuum: approaches to HIV/AIDS eradication and to enhanced immuno-therapy Paul Wender, Stanford University, USA
9:45-10:15 Invited Lecture To be announced
10:15-10:45 Invited Lecture Structural studies of weak protein-ligand complexes by NMR: novel saturation transfer difference (STD) NMR approaches Jesús Angulo, Universidad de Sevilla, Spain
10:45-11:00 Flash Communications FC10. Javier Valverde Pozo, A fluorescence ICT sensor for aminopeptidase detection in live cells FC11. Joan Miguel-Ávila, Transition Metal Promoted Cycloadditions in Biologic Media FC12. Esther Jiménez Moreno, Acetals as acid-sensitive clevable linkers for the design of antibody-drug conjugates
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11:00-11:30 |
Coffee break + Poster session 1 |
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11:30-13:30 |
Session 5 Chair: Maria Jesús Vicent
11:30-12:00 Invited Lecture Bio-inspired Materials Based on Simple Peptidic Derivatives Beatriz Escuder, Universitat Jaume I, Castellón, Spain
12:00-12:30 Invited Lecture Nature-inspired DNA-based nanodevices for diagnostic and drug-delivery applications Francesco Ricci, University of Rome, Italy
12:30-13:00 Invited Lecture (sponsored by SEQT) Development of synthetic Toxin-Antitoxin-based therapeutic systems for cancer treatment Guillermo de la Cueva, Bionand, Spain
13:00-13:30 Oral Communications OC5. Chemo-Enzymatic Total Synthesis of Sorbicillinoid Natural Products Anna Sib, IIQ-CSIC, Seville, Spain OC6. Applying dynamic chemistry for miR-21 direct detection and quantification Antonio Delgado-González, University of Granada, Spain
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13:30-15:00 |
Lunch |
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15:00-16:30 |
Session 6 Chair: Óscar Millet
15:00-15:30 Invited Lecture (Young Investigator GEQB Award) Supramolecular Chemistry Synthesizing Artificial Biology Javier Montenegro, CIQUS, Santiago de Compostela, Spain
15:30-16:15 Oral Communications OC7. Dendrimers as a powerful tool in biomedicine. Applications in tissue regeneration processes and as biomarkers Yolanda Vida, University of Málaga, Spain OC8. Ruthenium-catalyzed redox isomerizations inside living cells Christian Vidal, CIQUS, Santiago de Compostela, Spain OC9. Fighting Resistances: Photoswitchable Antimicrobials Fully Operated under Visible Light Xavier Just-Baringo, IRB, Barcelona, Spain
16:15-16:30 Flash Communications FC13. Salvador Guardiola, Target-based de novo design of heterochiral cyclic peptides against the PD-1/PD-L1 interaction FC14. Guillermo Bañuelos Sánchez, Specific Reverse Transcriptase Inhibitors for Mammalian LINE-1 Retrotransposons FC15. Raik Artschawager, Towards the chemo-enzymatic synthesis of a N-glycomimetic library for the targeting of human DC-SIGN
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16:30-17:00 |
Coffee break + Poster session 2 |
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17:00-18:30 |
Session 7 Chair: Ana Conejo
17:00-17:45 Oral Communications OC10. Dynamic stereoselection of kinetically-inert DNA-binding metallopeptide cylinders Miguel Vázquez-López, CIQUS, Santiago de Compostela, Spain OC11. GaudiMM: Opening New Horizons in Molecular Modeling of Chemobiological Systems Jean-Didier Maréchal, UAB, Barcelona, Spain OC12. Quinolimide-based probes: New tools to study protein-protein interactions Juan Antonio González-Vera, University of Granada, Spain
17:45-18:30 Plenary Lecture Size matters! Controlling the cellular microenvironment yields new insight into the inner working of cells Wilhelm T. S. Huck, Radboud University, The Netherlands
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20:30 |
Conference dinner |
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February 21st, 2020 |
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9:00-11:00 |
Session 8 Chair: Sonsoles Martín Santamaria
9:00-9:45 Plenary Lecture Breaking the limits in understanding glycan recognition by NMR Jesús Jiménez-Barbero, Cicbiogune, Bilbao, Spain
9:45-10:15 Invited Lecture The design of mGlu2 NAMs for neuropsychiatric disorders and studies towards potential tracers for PET imaging Michiel Van Gool, Janssen, Toledo, Spain
10:15-10:45 Invited Lecture Conformational landscapes in enzyme design Silvia Osuna, Universitat di Girona, Spain
10:45-11:05 Flash Communications FC16. Lucía Tapia, Efficient tyrosine trapping by the supramolecular protection from Src phosphorylation FC17. Mantas Liutkus, Modular Artificial Light Harvesting Systems
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11:00-11:30 |
Coffee break + Poster session 2 |
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11:30-13:30 |
Session 9 Chair: Eugenio Vázquez
11:30-12:30 Oral Communications OC13. Non-coding RNAs delivered by Magnetic and Gold Nanoparticles for the treatment of Uveal Melanoma Álvaro Somoza, IMDEA, Madrid, Spain OC14. G-quadruplex DNA Structures as Drug Targets for Small Molecules Jorge González García, University of Valencia, Spain OC15. Studying the Reaction Mechanism of Orotate Phosphoribosyltransferase by means of X-ray Crystallography and Computational Simulations Maite Roca, Universitat Jaume I, Castellón, Spain OC16. (Best PhD thesis GEQB Award) To be announced
12:30-13:00 Invited Lecture Bioorthogonal turn-on photosensitizers Olalla Vázquez, Philipps-Universität Marburg, Germany
13:00-13:30 Invited Lecture NMR and biosynthetic gene cluster analysis strategies for the determination of the structure and full absolute configuration of complex microbial natural products Fernando Reyes, Fundación Medina, Granada, Spain
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13:30-13:45 |
Closing remarks & Best GEQB Flash & Poster awards |
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13:45-15:00 |
Mini-Lunch |